Interleukin 23 Expression in Pyoderma Gangrenosum and Targeted Therapy With Ustekinumab

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Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab.

BACKGROUND Interleukin (IL)-23 is involved in the pathogenesis of the chronic inflammatory Crohn disease. Pyoderma gangrenosum (PG) is often associated with and can even be the first manifestation of this disease and has abundant neutrophilic infiltration. Because IL-23 plays a critical role in driving inflammation associated with IL-17 production and especially neutrophil recruitment, we suspe...

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Pyoderma gangrenosum associated with alitretinoin therapy.

PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition, the etiology of which is poorly understood but is thought to be related to improper neutrophil function and chemotaxis. PG is a clinical diagnosis that requires exclusion of other ulcerative and inflammatory cutaneous disorders. A rare side effect of isotretinoin is the development of ...

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Adalimumab Therapy for Recalcitrant Pyoderma Gangrenosum

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Pyoderma gangrenosum.

Pyoderma gangrenosum (PG) is an idiopathic, ulcerative, noninfective chronic inflammatory skin disorder of unknown etiology. It is associated with systemic medical illness in 50% of cases like inflammatory bowel disease, systemic arthritis, haematological diseases and malignancies. Characteristic lesions begin as pustule or vesiculopustule and progresses to an ulcer or deep erosion with violace...

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Dear Editors, Pyoderma gangrenosum is a rarely diagnosed neutrophilic disease, which is clinically characterised by very painful ulcers with violaceous, undermined borders (1–3). Even if aetiology and pathogenesis are still not completely understood an association with other systemic diseases, especially inflammatory bowel diseases, was frequently reported. Currently, other relevant comorbiditi...

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ژورنال

عنوان ژورنال: Archives of Dermatology

سال: 2011

ISSN: 0003-987X

DOI: 10.1001/archdermatol.2011.168